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Centrifuge Has Great Potential In The Pharmaceutical Field

Feb. 26, 2021

As one of the indispensable equipment in the pharmaceutical industry, the Centrifuge has been developing rapidly. Centrifuges are widely used in the medical field, and centrifuges are widely used in blood separation, virus research, DNA research, and drug purification. Centrifugation is to use the powerful centrifugal force generated by the high-speed rotation of the centrifuge rotor to accelerate the sedimentation speed of the particles in the liquid, and separate the substances with different sedimentation coefficients and buoyancy densities in the sample.

The Pharmaceutical Centrifuge has the characteristics of good adaptability, high degree of automation, stable operation, strong manufacturability, good corrosion resistance, good operating environment, complete and reliable safety protection devices, and beautiful appearance. The centrifuge used in the refining process such as drug purification is a general low-speed centrifuge with a speed of 4000 rpm or less and a large processing capacity. In order to meet the GMP specifications and requirements in the production of drugs, flat stainless steel materials are generally used.



In terms of function, the pharmaceutical centrifuge has the following advantages:

1.The material has strong adaptability. It can separate millimeter-level fine particles by selecting appropriate filter media, and can also be used for dehydration of finished articles. The articles can be cleaned through the water washing pipe.

2. The manual upper unloading type has simple structure, convenient installation, low cost, easy operation, and can maintain the crystal grain shape of the product.

3. The machine adopts advanced elastic support structure, which can reduce the vibration caused by uneven load, and the machine runs smoothly.

4. The entire high-speed running structure is concentrated in a closed shell, which can achieve sealing and avoid contamination of materials.

For the low-speed centrifuge, due to the strict regulations of the pharmaceutical industry, it basically adopts a flat-plate closed type. In order to reduce possible pollution or damage or improve sanitation, stainless steel materials are used for the parts in contact with materials or the whole machine is made of stainless steel materials. The whole machine has no sanitary dead corners. Clean and easy to use, this type of centrifuge has basically been used throughout the pharmaceutical industry. Together with the small centrifuge of about 3000 rpm for blood separation, it constitutes the entire low-speed industrial centrifuge system. It also penetrates into other industries related to biomedicine. . This type of centrifuge must comply with national GMP regulations before being used.

The High-Speed Centrifuge uses a DC brushless motor, maintenance-free; microcomputer control, can pre-select the speed, time, centrifugal force, liquid crystal display, easy to operate; 10 kinds of lifting speeds for selection, quick start, quick stop; stainless steel container room, electronic Door lock, early warning and alarm function, multiple protections, safe and reliable.

The technology of this type of centrifuge is relatively simple. Generally, a zone centrifuge is used. The zone centrifuge separates and collects cells, viruses, and DNA molecules according to the density and gradient of the sample solution. The sample loading and loading are both continuous Method, in addition to being widely used in production processes, is now also widely used in laboratory equipment. 


In the pharmaceutical industry, due to the stricter requirements for production quality and production safety, the main process equipment of the API production process in the pharmaceutical production field such as centrifuges also has extremely high requirements. In addition to maintaining its own separation characteristics, centrifuges also need to meet relevant regulations and standards in the medical field. Pharmaceutical centrifuges need to consider material, structure, material input and output methods, safety, labor intensity, control, cleaning or disinfection and sterilization from the perspective of meeting the requirements of the pharmaceutical production process.

Pharmaceutical centrifuges have cleaning and sterilization requirements when changing batches and varieties during production to prevent various sources of pollution and avoid re-pollution. Pharmaceutical centrifuges need to work hard in the areas of automatic program control, man-machine isolation operation, easy cleaning, sterilizable structure, online analysis, and research and improvement of separation methods for materials with different characteristics, to improve functions, control, and aseptic operations Level.

Since centrifuges in the medical field must be released from medicines, the surface of the centrifuge equipment must be smooth, flat, and free of dead corners. Therefore, it must be ensured that the sharp corners, corners, and welds of the centrifuge are ground into a smooth transitional circle during the production process. angle. Since it needs to be in contact with the medicine, the centrifuge needs to be corrosion resistant, and not chemically change with the medicine or adsorb the medicine.

With the development of centrifuges, related technologies of centrifuges have been improved. However, the pharmaceutical industry cannot settle for the status quo and must continue to move forward. With the support of national policies, centrifuge companies must continue to work hard to promote the wider application of centrifuges in the pharmaceutical industry.

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